Stress Ulcer Prophylaxis Introduction

The development of “stress” ulceration in the upper gastrointestinal (GI) tract has been part of critical care folklore since the beginning. In 1842 Curling described a series of severe duodenal ulceration associated with burns; in 1832 Cushing reported ulcer disease associated with surgery and trauma. In the early years of intensive care, a strong association between severity of illness and the incidence of GI bleeds was established. Patients who had major bleeds had a high mortality rate, and, consequently, prophylaxis against this complication has become a central issue in ICU care. The objective of this tutorial is to give you an idea of the incidence, causes and risks associated with stress ulceration. We will also address the potential complications associated  with prophylaxis.

Learning Objectives

• To learn about the causes of stress ulceration

• To evaluate the incidence and cost effectiveness of prophylaxis,

• To explore the literature, addressing which agent is most effective at prophylaxis.

• To determine the complications associated with ulcer prophylaxis,

Please note: these tutorials are for personal study purposes only.  They are not currently peer reviewed, and no responsibility will be taken for mistakes or inaccuracies. Reproduction of information is forbidden. All material is copyrighted by the GasWorks Group.