Dialysis Disequilibrium Syndrome




The dialysis disequilibrium syndrome is a self-limited condition characterized by nausea, vomiting, headache, altered consciousness, and rarely seizures or coma. It typically occurs after a first dialysis in very uremic patients. The syndrome is triggered by rapid movement of water into brain cells following the development of transient plasma hypo-osmolality as solutes are rapidly cleared from the bloodstream during dialysis. The incidence of this complication has fallen in recent years with the more gradual institution of dialysis, and the precise prescription of dialysis to include such variables as membrane size, blood flow rate, and sodium profile.




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