Introduction & Learning Objectives What is The Sepsis Paradigm? What is meant by SIRS, sepsis and septic shock? Describe the Inflammatory Cascades What Vascular Injuries occur in sepsis? What is the role of Nitric Oxide in sepsis? What are the Mechanisms of Peripheral Vascular Failure and Capillary Leak in SIRS? Describe the Imbalance of Coagulation and Fibrinolysis in sepsis What is the role of Activated Protein C in sepsis? How does sepsis effect the various organs of the body? What is The Gut Origin Theory? What is the Lung Origin Theory? Key Points (movie) References
