What is Sepsis?  Activated Protein C

     
       

 

         
       

Protein C is an important player in the body’s response to inflammation, systemic sepsis and the concomitant intravascular coagulopathy. The main effect of protein C is to reduce the production of thrombin, by inactivating factors Va and VIII. As we have seen, thrombin is proinflammatory, procoagulant and antifibrinolytic (16). In addition, protein C inhibits the influence of tissue factor on the clotting system, reduces the production of IL-1, IL-6, and TNF-α by monocytes, and has profibrinolytic properties by inactivating PAI-1 (it inactivates the inhibitor of the activator of the agent that converts plasminogen into plasmin)(17).

There is now compelling evidence that the exogenous administration of activated protein C to patients, in severe sepsis, improves outcome (18), presumably by the mechanisms described above. Note, however, that the use of this agent must be balanced by the risk of increased bleeding.

Figure: role of activated protein c in sepsis

if you cannot see this image, you need Macromedia Flash

References

CLICK HERE FOR REFERENCES

         
                   
       

         
     


THIS TUTORIAL BY PATRICK NELIGAN MD, UNIVERSITY OF PENNSYLVANIA

       
       

 

Please note: these tutorials are for personal study purposes only.  They are not currently peer reviewed, and no responsibility will be taken for mistakes or inaccuracies. Reproduction of information is forbidden. All material is copyrighted by the GasWorks Group.